From 6/07 Newsmax:
"When she stood before the TV cameras Sunday night during the televised CNN debate between Democrat hopefuls, Hillary Clinton raised a lot of eyes: suddenly the years had melted away and there was a young and flawless looking Mrs. Clinton. You could almost hear what viewers were thinking: did she use botox?"

There are photos that I see over a year ago showing a 60-year old woman, now I see someone with the skin of a 46 year old.
I know . . . I know . . . stick to the issues. 
BUT - if you want a topic that will drive the MSM crazy and attract readers like a Michael Jackson story. Run this one. 
Show the Before/After photos. 
I know that many women out there have had Botox. I have nothing against that. I am not saying it is bad or good. All I am saying is that it will position Obama's opponent as a vain, self-centered, monster (whoops, off the record) and not a real, thoughtful, and professional statesman.
From the Daily Mail:

"When you are running for president, your appearance is scrutinised almost as closely as your policies. So when Hillary Clinton appeared in a television debate looking years younger tongues were soon wagging.

Observers said the 60-year-old appeared youthful and fresh-faced, prompting speculation that she has had Botox injections."