Sen. Edward M. Kennedy will undergo surgery Monday at Duke University Medical Center for his cancerous brain tumor, his office said.

The 76-year-old senator was diagnosed last month with a malignant glioma, an especially lethal type of brain tumor. A statement from the Massachusetts Democrat's office said he would be operated on Monday morning in Durham, N.C., by Dr. Allan Friedman, followed by chemotherapy and radiation. Anthony Coley, a Kennedy spokesman, said the surgery is expected to begin around 9 a.m. It is expected to last about six hours.

"I am deeply grateful to the people of Massachusetts and to my friends, colleagues and so many others across the country and around the world who have expressed their support and good wishes as I tackle this new and unexpected health challenge," Kennedy said in the statement. "I am humbled by the outpouring and am strengthened by your prayers and kindness."

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